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World renowned journalist Sara Ogden is traversing the world in pursuit of carriers of a fatally dangerous "Stamp of Cain" in order to prevent seemingly unrelated events such as mass murders, turmoil, revolutions and chaos. She doesn't even suspect how close she is to the edge of the abyss, when in her search she ends up in Belarus to meet face to face with the one, whom she ha...。时为1982年，一支隶属挪威的三人南极科考队在冰原中行进，意外发现一艘一百万年前的奇怪船只，并且在附近找到了冻于严冰之中的神秘生物。才貌双全的美国古生物学家凯特·洛伊德（玛丽·伊丽莎白·文斯蒂德 Mary Elizabeth Winstead 饰）在桑德尔·哈沃森博士（Ulrich Thomsen 饰）的邀请下，随同一众科研工作者前往南极。经过认真研究，他们发现这是地球上从未有过的生物。正当科学家们为了这个伟大的发现载歌载舞庆祝之时，神秘生物悄悄解冻，继而向人类展开凶残的袭击。经过一番惨烈的搏斗，怪物最终葬身火海。 但是厄运并未就此结束，经过对怪物细胞的观测，凯特隐隐感到一场灾难正向全人类袭来……。